Isothermal microcalorimetry is the perfect tool to measure thermogenesis. There are many techniques that claim to measure metabolism and thermogenesis but they use proxy measurements such as oxygen or metabolite depletion. Isothermal microcalorimetry is the only method that measures heat which is a direct measurement of thermogenesis and a way to measure metabolism without bias.
The calScreener™ is a powerful instrument capable of extremely sensitive measurements of thermogenesis. The instrument is simple to use and flexible, able to accommodate many different cell types or clinical biopsies.
When studying thermogenesis, don’t settle for proxies. Get a true and accurate reading of minute changes of the heat from your sample in real time.
Whether your samples float or sit at the bottom of a culture dish, our calScreener plates can handle it all.
Our calScreener™ produces a thermogram which gives a high-resolution picture of small changes in the energy profile of a sample over time.
One of the key benefits of the calScreener™ for measuring thermogenesis is that it doesn’t matter where the sample sits in our specialised plate, our sensitive technology will be able to pick up the heat signal regardless. This is perfect for cells with irregular growth behavior or cells that do not sit comfortable at the bottom of culture dish.
Thermogenesis is the production of heat. Microcalorimetry measures the production of heat. There is no better match. There are other techniques that measure thermogenesis by measuring metabolite production in known thermogenesis pathways. However, if something changes during the experiment or thermogenesis occurs via another pathway, these proxy methods will not only give inaccurate results, but there will be no way of knowing that they are wrong. Microcalorimetry on the other hand allows you to be confident in your measurements and gives you data that you can trust. Thermogenesis researchers are using microcalorimetry to uncover new and exciting results that would not have been possible using other methods.